What is the Most Effective Charity to Donate To?

Patrick Windley

March 24, 2023

Charity to Donate

Choosing the most effective charity to donate to can be a complex decision. It depends on your values and worldview.

But research has shown that charitable donations can make you feel happier and more fulfilled, so it’s worth considering it seriously. To help, we’ve compiled a list of charities proven to do more good for every dollar they receive.

American Humane

If you’re donating to an animal charity, finding one that will make the most impact is crucial. You can do this by researching the organization’s website and its finances.

American Humane is a top-rated charity with 88 cents of every dollar donated to programs. Their goals include protecting animals from cruelty, promoting the bonds between pets and humans, and helping needy animals.

They also help rescues and shelters and bring military dogs home. In addition, they support the development of animal-assisted therapy for veterans and children with cancer.

Petco is an American Humane Certified “Pet Provider” with a long history of egregious animal suffering at its stores and suppliers. Undercover investigations have shown dead fish in their crates, faeces piling up in cages, sick animals in severely crowded containers, and reptiles deprived of proper heat at its stores.

Cancer Research Institute

The Cancer Research Institute is one of the most effective charities to donate to because it has a unique model that focuses on immunotherapy research. It funds the best innovative research and invests in clinical trials.

CRI’s network of international scientists enables it to pool resources and accelerate the discovery of new therapies for cancer. The Institute puts 88 cents out of every dollar donated toward research on immune-based treatment for all types of cancer.

The Leukemia & Lymphoma Society is dedicated to curing blood cancers such as Leukemia, lymphoma, and Hodgkin’s disease. They do this through research, education, support, and advocacy.


Faunalytics connects animal advocates to research that is relevant to their work. This involves conducting original studies, promoting existing studies in their library and video series, and responding to requests from advocates for studies that they think will be useful.

They also offer a unique Office Hours program that provides animal advocates one-on-one advice on research design, strategy and general knowledge questions.

Their researchers include PhD-level trained social scientists and statisticians with years of experience in the research field. However, the fact that like-minded animal extremists review their studies before being published is very concerning.

Their research is often of very high quality and is likely to help the animal advocacy movement become more effective. The organization’s leadership, including founder Che Green and research director Jo Anderson, is incredibly dedicated to this mission.

Malaria Consortium

Malaria is a disease that kills more than 400,000 people each year, predominantly children under the age of 5. It costs individuals and nations billions of dollars annually in lost productivity, medical costs, burial expenses, and lost productivity of families and communities.

Using various strategies and programmes, Malaria Consortium tackles the spread of malaria and related parasitic diseases. Its seasonal malaria chemoprevention (SMC) programme distributes preventative antimalarial drugs to young children during peak transmission rates, reducing disease burden and saving lives.

Malaria is a significant driver of poverty in Africa. Donations to anti-malaria (non-Covid) vaccination and vitamin A supplementation programs are among the best ways to help fend off its deadly effects. The Covid-19 pandemic has also taxed health systems, putting further pressure on these programs, so donations are critical to protecting those who need them most.

Helen Keller Intl

Helen Keller International combats the causes and consequences of blindness and malnutrition by establishing programs based on evidence and research in vision, health and nutrition.

Founded in 1903, HKI benefits millions of people each year by helping prevent and cure debilitating diseases linked to poverty that often cause severe physical and mental disabilities. These diseases include trachoma, cataract, onchocerciasis (river blindness), and refractive error.

The organization’s top-rated program is vitamin A supplementation, which saves lives by preventing and treating eye disease caused by a deficiency in the body’s natural antioxidants. It also provides technical assistance, advocacy, and funding.